Most likely not, it all judges on the velocity and how big the round is. For sure a 5.7 will go through it. It goes at a whopping 850 m/s (2,800 ft/s). It is only 90 m/s slower that a 5.56 x 45 and it is significantly smaller. However looking at your wording will the two rounds stop someone in a bullet proof vest, then yes. No one will be messing with you have being hit with a .45 or a .50 armor or not.